The Winter Sanctuary will provide shelter, meals and services through the end of March.
Maya Wallace, with Sacramento Steps Forward, says while homelessness is a year-round problem, housing is especially critical in the winter.
She says getting homeless people off the streets is the first step to turning lives around.
"And that's anything from giving people rental assistance to motel vouchers to emergency shelter. And that's across a range of populations that's chronically homeless, folks with mental health issues, families, youth."
Meals and other services are donated or paid for with donations. She says about 100 people use the shelter each night.