Harrisburg scored the first goal of the match off of a turnover in Sacramento's zone in the sixth minute.
Sacramento tied the score on a corner kick by Sacramento State alum, Max Alvarez to Davis native, Adam Jahn.
Morgan Langley of Harrisburg put a spin move on his defender in the 52nd minute and put the ball in the lower right corner of the net for the game winner.
Sacramento had a half-dozen corner kicks late in the match, but were unable to convert.
The official attendance of 22,031 at Hughes Stadium set a USL Pro regular season attendance record.
The team debuted, as did the Tower Bridge Battalion -a group of 100 fans who marched into Hughes Stadium waving banners and singing songs.
The team will play two more home games before moving to Bonney Field at Cal Expo in June.
Sacramento's next home game is Saturday, May 3rd.