St. David Moranz with the Citrus Heights Police Department said the woman in her 20s rammed into a police car when officers tried to pull her over around 11:30 a.m. Sunday in Fair Oaks.
He said she took off, leading the officers on a high-speed chase in which she drove on the wrong side of the road.
The chase ended when she rammed into another police car. Moranz said two officers in that car feared for their safety and fired several rounds into the suspect's car, fatally striking her.
The Sacramento Sheriff's department is investigating the shooting because it happened in an unincorporated area of the county.
This incident was the second shooting reported over the weekend. Early Sunday, authorities said two Sacramento County Sheriff's deputies shot and killed an armed man near Antelope Road.
The City of Sacramento recorded a drop in crime of 14-percent last year compared to 2013 and the lowest homicide rate in four decades.
A new report lays out how much it cost California to lock up juvenile offenders.
A measure on the California November ballot would reduce some drug possession and theft-related felony crimes to misdemeanors. Proponents say it would reduce prison overcrowding and prison costs. Opponents say it would put dangerous criminals back on the streets and overcrowd local jails.
Stockton Police are looking to question a man who might have dropped off the gunmen in the Bank of the West robbery and shootout in July.
After a dramatic drop in Stockton's homicide rate over the last couple of years, the violent death numbers are going back up again.